Consumed By Edit
During the Majin Buu story arc, Piccolo acts as a tutor to Son Goten and Trunks so that they can learn the fusion dance and fight Majin Buu. The two eventually master the fusion dance and transform into Gotenks. They then battle Majin Buu and Piccolo aids them. They appear to be evenly matched, but soon run into trouble when the time limit on the fusion runs out. Luckily, Goten's older brother Son Gohan shows up just in time and easily overpowers Buu.
After blowing himself and disappearing for some time, Buu reappears and asks Goten and Trunks to fuse back into Gotenks, claiming that he wants to battle them. Goten and Trunks oblige Buu's request and perform the fusion dance, turning back into Gotenks. However, it turns out to be a trap as Piccolo and Gotenks are immediately engulfed by large pink blobs; pieces of Majin Buu that he had broken off earlier. Once Piccolo is completely covered by the blob, he is flung into Buu's body and absorbed.
Shortly afterwards, Son Goku returns from the dead to fight alongside Gohan, but Gohan is also absorbed. Goku then fuses with the Saiyan Vegeta, becoming Vegito, and easily overpowers Buu. Vegito then allows himself to be absorbed by Buu so that he can rescue Piccolo and the others and succeeds in doing so. After being released from Buu's body, Piccolo dies when Buu blows up Eath, but is resurrected afterwards and aids in forming the Spirit Bomb that ultimately destroys Buu.